Discuss the role of the retinoic acid in signalling neural regeneration.
Description
Sistematic review of 5/6 scientific papers.
Choose similar studies to compare, something in vivo and in vitro.
How applicable, parallel studies
In vitro, look for same effects of the RA (cell proliferation)
Neural differentiation and neural outgrowth, is regen. RA alpha receptors, need activators for RA to work
Comparable studies in vivo, animal studies. Mouse trials & monkeys
In vitro, jonathan colcoran
In vivo, alzheimers and in
5 papers for each study,
Focus on neural development.
Table of Contents
1. Introduction
1.1 Retinoic acid
1.2 Mechanism of action and metabolism of the Retinoic Acid
1.3 Retinoic acid biosynthesis
1.4 Retinoic Acid Signalling Pathways
1.5 Retinoic Acid Signalling Neural Development
1.6 The Role of Retinoic Acid Signalling Neural Regeneration
2. Methods
2.1 Literature search strategy
2.2 Study Selection and Data extraction
2.3 Outcome selection and measurement
2.4 Data Extraction
2.5 Statistical Analysis
3.0 Results
3.1 Study selection
3.2 result of method
4.0 Discussion
Use similar titles as above, similar structure
5.0 Conclusion
6.0 References
7.0 Appendixes