Rei’s work colleague, Kurt, is a 53-year-old father, who has worked as a gardener all his life. He has
been diagnosed with stage IVA melanoma. Kurt underwent removal of the melanoma on his left
forearm and a nearby lymph node dissection 7 weeks ago. He has been receiving immunotherapy for
his melanoma which has not been successful and therefore he has been placed on chemotherapy.
Kurt has been experiencing weight loss over the last 2 months as well as a persistent cough and
shortness of breath. A CT scan reveals several, well circumscribed, rounded structures in the
periphery of his lungs. A lung biopsy is performed, which confirms the presence of melanoma cells in
the structures observed on the CT image.
Question 2/9. Discuss the significance of Kurt’s CT and histology findings. (2 marks)
Question 2/10 Further laboratory testing has indicated a p53 gene mutation in Kurt’s melanoma
cells. Explain the possible link between Kurt’s p53 mutation and his melanoma, and
considering Kurt’s profession, name a possible environmental factor that may have
caused his mutation. (3 marks)
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